A non-pneumatic tire comprising one or more radial regions have differing Shore A/Shore D hardness. The non-pneumatic tire comprises side cavities that are staggered with respect to laterally opposing side cavities, and laterally extending tread grooves that are in substantial radial alignment with or substantially offset relative to the cavities. One radial region may comprising the side cavities, while another radial region with a different hardness comprises the tread grooves. Also provided are processes for making such tires and to off-the-road (OTR) vehicles employing such tires.