发明授权
US09139638B2 Mouse model of cholinergic dysfunction to evaluate cognitive enhancers and drugs that improve myasthenia
有权
胆碱能功能障碍的小鼠模型来评估改善重症肌无力的认知增强剂和药物
- 专利标题: Mouse model of cholinergic dysfunction to evaluate cognitive enhancers and drugs that improve myasthenia
- 专利标题(中): 胆碱能功能障碍的小鼠模型来评估改善重症肌无力的认知增强剂和药物
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申请号: US11842406申请日: 2007-08-21
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公开(公告)号: US09139638B2公开(公告)日: 2015-09-22
- 发明人: Marc G. Caron , Vania F. Prado , Marco A. Prado , Raul Gainetdinov , Grace S. Pereira , Braulio M. Castro , Cristina M. Silva , Ivan A. Izquierdo
- 申请人: Marc G. Caron , Vania F. Prado , Marco A. Prado , Raul Gainetdinov , Grace S. Pereira , Braulio M. Castro , Cristina M. Silva , Ivan A. Izquierdo
- 申请人地址: US NC Durham BR Belo Horizonte
- 专利权人: Duke University,Universidade Federal de Minas Gerais
- 当前专利权人: Duke University,Universidade Federal de Minas Gerais
- 当前专利权人地址: US NC Durham BR Belo Horizonte
- 代理机构: Myers Bigel Sibley & Sajovec, P.A.
- 主分类号: A01K67/027
- IPC分类号: A01K67/027 ; C07K14/705 ; C12N15/85
摘要:
Recombinant non-human mammals having reduced or no expression of vesicular acetylcholine transporter protein (VAChT) as compared to the corresponding wild-type mammal are provided. The mammal may have, e.g., impaired performance in object and social recognition and/or impaired neuromuscular performance and/or alterations in autonomic nervous system function as compared to the corresponding wild-type mammal. Methods of screening a compound for cholinergic activity or activity in treating a cholinergic neurotransmission disorder are also provided. In addition, a cell such as a nerve cell isolated from a mammal as described herein is provided, along with cell cultures, which are useful in vitro for screening the activity of candidate compounds for their effect on cholinergic neurotransmission, and for their activity in treating cholinergic neurotransmission disorders.