A catalyst separation system which separates catalyst particles from liquid hydrocarbons synthesized by a chemical reaction of a synthesis gas including a hydrogen and a carbon monoxide as the main components, and a slurry having solid catalyst particles suspended in a liquid, the catalyst separation system is provided with: a reactor; a storage tank which stores the slurry drawn from the reactor; a plurality of filters which filters the slurry; and a filtrate recovery vessel which recovers a filtrate which has passed through the plurality of filters, wherein the plurality of filters is disposed in series in a flow line for the slurry from the storage tank to the filtrate recovery vessel.