发明授权
- 专利标题： Polymers and the preparation of nanogel drug cocktails
- 专利标题（中）： 聚合物和制备纳米凝胶药物鸡尾酒
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申请号： US13929981申请日： 2013-06-28
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公开(公告)号： US09149535B2公开(公告)日： 2015-10-06
- 发明人: Peisheng Xu , Remant Bahadur K.C.
- 申请人： Peisheng Xu , Remant Bahadur K.C.
- 申请人地址： US SC Columbia
- 专利权人： University of South Carolina
- 当前专利权人： University of South Carolina
- 当前专利权人地址： US SC Columbia
- 代理机构： Dority & Manning, P.A.
- 主分类号： A61K47/42
- IPC分类号： A61K47/42 ; A61K47/32 ; C08F216/04 ; C08F8/34 ; C08F226/06 ; A61K9/51 ; A61K47/48 ; C08F8/04
摘要：
Methods for forming, modifying, and drug loading of a copolymer are provided, along with the resulting products. The method can include polymerizing 2-(pyridin-2-yldisulfanyl)ethyl acrylate with poly(ethylene glycol)methacrylate via free radical polymerization to form the copolymer. The molar ratio of 2-(pyridin-2-yldisulfanyl)ethyl acrylate to poly(ethylene glycol)methacrylate is about 100:1 to about 1:100. After polymerizing, the copolymer can be reacted with a thiol monomer that contains a carbon-bonded sulfhydryl to modify end groups on a first portion of the 2-(pyridin-2-yldisulfanyl)ethyl acrylate repeating units. Thereafter, the copolymer can be crosslinked, and a drug can then be loaded into the crosslinked copolymer.
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