Invention Grant
US09150540B2 Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors
有权
四氢苯并蒽醌和四氢环戊基喹啉酮作为parp和微管蛋白聚合抑制剂
- Patent Title: Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors
- Patent Title (中): 四氢苯并蒽醌和四氢环戊基喹啉酮作为parp和微管蛋白聚合抑制剂
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Application No.: US14513814Application Date: 2014-10-14
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Publication No.: US09150540B2Publication Date: 2015-10-06
- Inventor: Patrick Rene Angibaud , Laurence Anne Mevellec , Bruno Roux , Pierre-Henri Storck , Christophe Meyer , Jorge Eduardo Vialard
- Applicant: Janssen Pharmaceutica, NV
- Applicant Address: BE
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE
- Priority: EP08153432 20080327
- Main IPC: C07D401/06
- IPC: C07D401/06 ; C07D221/12 ; A61K31/4353
Abstract:
The present invention provides compounds of formula (I), their use as inhibitors of tubulin polymerization and their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and Y have defined meanings.
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