发明授权
- 专利标题： ILT3 polypeptides and uses thereof
- 专利标题（中）： ILT3多肽及其用途
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申请号： US13480421申请日： 2012-05-24
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公开(公告)号： US09150635B2公开(公告)日： 2015-10-06
- 发明人: Nicole Suciu-Foca , Luigi Scotto , Seunghee Kim-Schulze , George Vlad , Raffaello Cortesini
- 申请人： Nicole Suciu-Foca , Luigi Scotto , Seunghee Kim-Schulze , George Vlad , Raffaello Cortesini
- 申请人地址： US NY New York
- 专利权人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 当前专利权人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 当前专利权人地址： US NY New York
- 代理机构： Beusse Wolter Sanks & Maire, PLLC
- 代理商 Judith A. Evans
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; C07K14/705
摘要：
This invention provides a first polypeptide comprising all or a portion of the extracellular domain of ILT3, wherein the polypeptide is water-soluble and does not comprise the Fc portion of an immunoglobulin. This invention also provides a second polypeptide comprising (i) all or a portion of the extracellular domain of ILT3 operable affixed to (ii) the Fc portion of an immunoglobulin, wherein the Fc portion of the immunoglobulin comprises a function-enhancing mutation, and wherein the polypeptide is water-soluble. This invention further provides a third polypeptide comprising (i) all or a portion of the extracellular domain of ILT3 operable affixed to (ii) a transmembrane domain. This invention further provides related nucleic acids, expression vectors, host vector systems, compositions, and articles of manufacture and therapeutic and prophylactic methods using the polypeptides of the invention.
公开/授权文献
- US20120321623A1 ILT3 Polypeptides and Uses Thereof 公开/授权日：2012-12-20
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