发明授权
US09150926B2 Diagnosis and treatment of adrenocortical tumors using human microRNA-483
有权
使用人microRNA-483诊断和治疗肾上腺皮质肿瘤
- 专利标题： Diagnosis and treatment of adrenocortical tumors using human microRNA-483
- 专利标题（中）： 使用人microRNA-483诊断和治疗肾上腺皮质肿瘤
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申请号： US12961298申请日： 2010-12-06
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公开(公告)号： US09150926B2公开(公告)日： 2015-10-06
- 发明人: Electron Kebebew , Erin Patterson
- 申请人： Electron Kebebew , Erin Patterson
- 申请人地址： US DC Washington
- 专利权人： The United States of America, as Represented by the Secretary, Department of Health and Human Services
- 当前专利权人： The United States of America, as Represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址： US DC Washington
- 代理机构： Klarquist Sparkman, LLP
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12P19/34 ; C12N5/00 ; C12N5/02 ; C12N15/113
摘要：
Disclosed herein are methods of diagnosing and treating a malignant adrenocortical tumor, including adrenocortical carcinoma. In some examples, methods of diagnosing a malignant adrenocortical tumor include detecting expression of at least one microRNA (miR) gene product, such as miR-100, miR-125b, miR-195, miR-483-3p, miR-483-5p and IGF2 mRNA in a sample obtained from the subject with an adrenocortical tumor and comparing expression of at least one of these miR gene products and IGF2 mRNA in the sample obtained from the subject to a control. Altered expression of at least one of the miR gene products and IGF2 mRNA, such as a decrease in miR-100, miR-125b or miR-195 or an increase in miR-483-3p, miR-483-5p, and an increase in IGF2 mRNA, in the sample obtained from the subject compared to the control indicates a malignant adrenocortical tumor.
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