发明授权
- 专利标题： Modified, hydroxy-substituted aromatic structures having cytoprotective activity
- 专利标题（中）： 具有细胞保护活性的改性羟基取代芳族结构
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申请号： US12888560申请日： 2010-09-23
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公开(公告)号： US09156876B2公开(公告)日： 2015-10-13
- 发明人: Douglas F. Covey
- 申请人： Douglas F. Covey
- 申请人地址： US MO St. Louis
- 专利权人： Washington University
- 当前专利权人： Washington University
- 当前专利权人地址： US MO St. Louis
- 代理机构： Armstrong Teasdale LLP
- 主分类号： A61K31/566
- IPC分类号： A61K31/566 ; A61K31/565 ; A61P25/00 ; A61P25/16 ; A61P25/28 ; A61P27/06 ; A61P27/12 ; A61P9/10 ; C07J1/00
摘要：
The present invention is directed to a process for conferring cytoprotection on a population of cells which comprises administering to that population of cells a compound comprising a hydroxy-substituted aromatic ring structure and a non-fused polycyclic, hydrophobic substituent attached thereto. In particular, the present invention is directed to such a process wherein the administered compound is phenolic, such as a steriod (e.g., estrogen), and has a non-fused polycyclic, hydrophobic substituent attached to the hydroxy-substituted A-ring thereof.
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