发明授权
US09163012B2 Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
有权
氨基甲酸酯和尿素抑制剂11＆bgr-羟基类固醇脱氢酶1
- 专利标题： Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
- 专利标题（中）： 氨基甲酸酯和尿素抑制剂11＆bgr-羟基类固醇脱氢酶1
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申请号： US12791592申请日： 2010-06-01
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公开(公告)号： US09163012B2公开(公告)日： 2015-10-20
- 发明人: David A. Claremon , Colin M. Tice , Linghang Zhuang , Katerina Leftheris , Yuanjie Ye , Suresh B. Singh
- 申请人： David A. Claremon , Colin M. Tice , Linghang Zhuang , Katerina Leftheris , Yuanjie Ye , Suresh B. Singh
- 申请人地址： US PA Fort Washington
- 专利权人： Vitae Pharmaceuticals, Inc.
- 当前专利权人： Vitae Pharmaceuticals, Inc.
- 当前专利权人地址： US PA Fort Washington
- 代理机构： McCarter & English LLP
- 代理商 Steven G. Davis; Michael J. DeGrazia
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; A61K31/50 ; A61K31/495 ; C07D239/42 ; A61K31/47 ; A61K31/445 ; A61K31/44 ; A61K31/41 ; C07D417/04 ; C07D207/16 ; C07D211/22 ; C07D211/34 ; C07D211/60 ; C07D401/12 ; C07D403/12 ; C07D413/04 ; C07D417/12 ; C07D471/04
摘要：
This invention relates to novel compounds of the invention pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.