- 专利标题： Anti-DLL4/VEGF dual variable domain immunoglobulin and uses thereof
-
申请号： US14068976申请日： 2013-10-31
-
公开(公告)号： US09163093B2公开(公告)日： 2015-10-20
- 发明人: Jijie Gu , Dominic J. Ambrosi , Susan E. Lappe , Yingchun Li , Jonathan A. Hickson , Deanna L. Haasch , Supriya Gupta , Ravi Chari , Camellia Zamiri , Louie Naumovski , Xianhua Cao
- 申请人： Jijie Gu , Dominic J. Ambrosi , Susan E. Lappe , Yingchun Li , Jonathan A. Hickson , Deanna L. Haasch , Supriya Gupta , Ravi Chari , Camellia Zamiri , Louie Naumovski , Xianhua Cao
- 申请人地址： US IL North Chicago
- 专利权人： AbbVie Inc.
- 当前专利权人： AbbVie Inc.
- 当前专利权人地址： US IL North Chicago
- 代理机构： Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K39/40 ; C07K16/46 ; A61K45/06 ; C07K16/22 ; A61K31/513 ; A61K31/7068 ; A61K31/337 ; A61K31/4745 ; A61K31/495 ; A61K31/525 ; C07K16/28 ; C07K16/00 ; A61K39/00
摘要：
Disclosed herein are multivalent and multispecific binding proteins, methods of making the binding proteins, and their uses in the diagnosis, monitoring, inhibition, prevention and/or treatment of cancers, tumors, and/or other angiogenesis-dependent diseases characterized by aberrant DLL4 and/or VEGF expression or activity.