Some demonstrative embodiments include devices, systems and methods of multi-channel processing. For example, a multi-channel data processor may process data of a plurality of channels, the multi-channel data processor is to switch from processing a first channel to processing a second channel of the plurality of channels by performing a context switch during a single clock cycle, the context switch including storing first state context corresponding to a processing state of the first channel and loading previously stored second state context corresponding to a processing state of the second channel.