In some implementations, a user can specify an audio control curve for an audio track. The audio track can include an audio signal that is sampled at a specified rate. The audio control curve can be used to generate an audio control signal that can be sampled at the same rate as the audio signal. The audio signal and the audio control signal can be combined to produce sample-accurate adjustments of the audio signal. In some implementations, the audio control curve can correspond to gain adjustments for the audio signal. In some implementations, the audio control curve can be used to adjust the amplitude of the audio signal at particular frequencies. The audio control curve can be used to adjust treble or bass levels during the playback of an audio track, for example.