Systems and methods reduce electromagnetic interference from high speed data carried by wired interconnects with a radio receiver for at least one protected radio frequency band. A spectral encoder changes the encoding of the high speed data to modify its frequency spectrum and reduce its spectral in the protected frequency band. The wired interconnect carries the spectrally encoded data to its destination, where it is spectrally decoded back to its original form. Spectral encoding may include polynomial scrambling. The data may be encoded with different coding parameters in parallel and the best result selected for communication over the wired interconnect. The coding parameters may be changed depending on which radio receivers and/or protected frequency bands are in use at any given time.