Invention Grant
- Patent Title: c-Met modulators and methods of use
- Patent Title (中): c-Met调制剂和使用方法
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Application No.: US11586751Application Date: 2006-10-26
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Publication No.: US09174947B2Publication Date: 2015-11-03
- Inventor: Lynne Canne Bannen , Diva Sze-Ming Chan , Jeff Chen , Lisa Esther Dalrymple , Timothy Patrick Forsyth , Tai Phat Huynh , Vasu Jammalamadaka , Richard George Khoury , James William Leahy , Morrison B. Mac , Grace Mann , Larry W. Mann , John M. Nuss , Jason Jevious Parks , Craig Stacy Takeuchi , Yong Wang , Wie Xu
- Applicant: Lynne Canne Bannen , Diva Sze-Ming Chan , Jeff Chen , Lisa Esther Dalrymple , Timothy Patrick Forsyth , Tai Phat Huynh , Vasu Jammalamadaka , Richard George Khoury , James William Leahy , Morrison B. Mac , Grace Mann , Larry W. Mann , John M. Nuss , Jason Jevious Parks , Craig Stacy Takeuchi , Yong Wang , Wie Xu
- Applicant Address: US CA South San Francisco
- Assignee: Exelixus, Inc.
- Current Assignee: Exelixus, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Honigman Miller Schwartz and Cohn LLP
- Agent Heidi M. Berven; Jonathan P. O'Brien
- Main IPC: C07D239/88
- IPC: C07D239/88 ; A61K31/47 ; A61K31/4709 ; A61K31/517 ; C07D215/22 ; C07D215/233 ; C07D295/15 ; C07D401/12 ; C07D401/14 ; C07D405/14 ; C07D413/14
Abstract:
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
Public/Granted literature
- US20070054928A1 c-Met modulators and methods of use Public/Granted day:2007-03-08
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