发明授权
- 专利标题： Antibody against human prostaglandin E2 receptor EP4
- 专利标题（中）： 抗人前列腺素E2受体EP4的抗体
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申请号： US13876763申请日： 2011-09-28
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公开(公告)号： US09175080B2公开(公告)日： 2015-11-03
- 发明人: Kiyoshi Takayama , Tomoko Shimizu , Yuji Urushibata , Yukihiko Sugimoto
- 申请人： Kiyoshi Takayama , Tomoko Shimizu , Yuji Urushibata , Yukihiko Sugimoto
- 申请人地址： JP Sapporo-Shi, Hokkaido
- 专利权人： NB HEALTH LABORATORY CO., LTD.
- 当前专利权人： NB HEALTH LABORATORY CO., LTD.
- 当前专利权人地址： JP Sapporo-Shi, Hokkaido
- 代理机构： Westerman, Hattori, Daniels & Adrian, LLP
- 优先权： JP2010-218158 20100929
- 国际申请： PCT/JP2011/072190 WO 20110928
- 国际公布： WO2012/043634 WO 20120405
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/28 ; C07K17/00 ; G01N33/88
摘要：
It is an object of the present invention to provide an antibody that binds to a human PGE2 receptor subtype EP4 and inhibits the function of EP4, or a functional fragment thereof. It is another object of the present invention to provide a medicament comprising the aforementioned antibody or a functional fragment thereof. Mice were immunized with the human PGE2 receptor subtype EP4, and a monoclonal antibody that suppresses the intracellular cAMP level increase induced by EP4 was screened. In addition, the CDR sequences of the obtained monoclonal antibody were determined.
公开/授权文献
- US20130197199A1 ANTIBODY AGAINST HUMAN PROSTAGLANDIN E2 RECEPTOR EP4 公开/授权日：2013-08-01