In various aspects, systems and methods are provided for integrated operation of molten carbonate fuel cells with turbines for power generation. Instead of selecting the operating conditions of a fuel cell to improve or maximize the electrical efficiency of the fuel cell, an excess of reformable fuel can be passed into the anode of the fuel cell to increase the chemical energy output of the fuel cell. The increased chemical energy output can be used for additional power generation, such as by providing fuel for a hydrogen turbine.