发明授权
- 专利标题： Mitochondrial ribosomal proteins as aging regulators
- 专利标题（中）： 线粒体核糖体蛋白作为老化调节剂
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申请号： US14239198申请日： 2012-08-20
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公开(公告)号： US09180134B2公开(公告)日： 2015-11-10
- 发明人: Johan Auwerx , Richardus Houtkooper , Laurent Mouchiroud
- 申请人： Johan Auwerx , Richardus Houtkooper , Laurent Mouchiroud
- 申请人地址： CH Lausanne
- 专利权人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPEL)
- 当前专利权人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPEL)
- 当前专利权人地址： CH Lausanne
- 代理机构： Saliwanchik, Lloyd & Eisenschenk
- 国际申请： PCT/IB2012/054206 WO 20120820
- 国际公布： WO2013/024467 WO 20130221
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; A61K31/65 ; A61K31/713 ; C12N15/113 ; G01N33/50 ; A61K31/165 ; A61K49/00 ; C12Q1/68
摘要：
The present invention relates to methods of increasing lifespan, delaying aging, and/or preventing or treating an age-related disease or a mitochondrial disease in a subject, comprising inducing a nuclear-mitochondrial OXPHOS protein dyssynchrony, including inhibiting the mitochondrial translation machinery function, as well as methods for screening agents that are able to increase lifespan, inhibit or delay aging, and/or prevent or treat an age-related disease or disorder, or a mitochondrial disease or disorder, in a subject.
公开/授权文献
- US20140187611A1 MITOCHONDRIAL RIBOSOMAL PROTEINS AS AGING REGULATORS 公开/授权日：2014-07-03
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