Invention Grant
![Substituted pyrrolo[2,3-B]pyridines as MLK inhibitors](/docs/US/2015-11-10/US09181247B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted pyrrolo[2,3-B]pyridines as MLK inhibitors
- Patent Title (中): 取代的吡咯并[2,3-B]吡啶作为MLK抑制剂
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Application No.: US14508566Application Date: 2014-10-07
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Publication No.: US09181247B2Publication Date: 2015-11-10
- Inventor: Harris A. Gelbard , Stephen Dewhurst , Val S. Goodfellow , Colin J. Loweth , Torsten Wiemann
- Applicant: The University of Rochester
- Applicant Address: US NY Rochester
- Assignee: The University of Rochester
- Current Assignee: The University of Rochester
- Current Assignee Address: US NY Rochester
- Agency: Meunier Carlin & Curfman LLC
- Main IPC: A61K31/437
- IPC: A61K31/437 ; C07D471/04 ; A61K45/06 ; C07D487/04
![Substituted pyrrolo[2,3-B]pyridines as MLK inhibitors](/abs-image/US/2015/11/10/US09181247B2/abs.jpg.150x150.jpg)
Abstract:
Provided are compounds having an inhibitory effect on Mixed Lineage Kinases. The compounds include substituted pyrrolo [2,3b]pyridines having Formula IX Also provided are pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by Mixed Lineage Kinase inhibition. Also provided are methods of treatment of neuropsychiatric disorders which comprise the inhibition of Mixed Lineage Kinases.
Public/Granted literature
- US20150105401A1 MLK INHIBITORS AND METHODS OF USE Public/Granted day:2015-04-16
Information query
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