A hand-held, power operated debridement tool (2000) includes a rotary disk knife blade (2300) with a cutting edge (2360) on an outer peripheral edge (2362) of the knife blade, the cutting edge defining a cutting plane (CP) of the disk knife blade. The debridement tool further includes an annular skin guide (2700) including an outer wall (2716) defining a skin contact surface (2720) disposed above the cutting plane (CP) of the disk knife blade and positioned radially inwardly of the disk knife blade cutting edge to receive and direct an excised layer of skin tissue (EST) cut by the disk knife blade upwardly away from the blade cutting edge. The debridement tool additionally includes an axially adjustable depth gauge (2620) including a depth gauge plate (2622) disposed above the cutting plane of the disk knife blade and positioned radially outwardly of the cutting edge of the disk knife blade.