Invention Grant
- Patent Title: Quinolyl-containing hydroxamic acid compound and preparation method thereof, and pharmaceutical composition containing this compound and use thereof
- Patent Title (中): 含喹啉的异羟肟酸化合物及其制备方法，以及含有该化合物的药物组合物及其用途
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Application No.: US14345922Application Date: 2011-09-27
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Publication No.: US09186318B2Publication Date: 2015-11-17
- Inventor: Ziwei Yun , Hongtao Wang
- Applicant: Ziwei Yun , Hongtao Wang
- Applicant Address: CN Beijing
- Assignee: Beijing Konruns Pharmaceutical Co., Ltd
- Current Assignee: Beijing Konruns Pharmaceutical Co., Ltd
- Current Assignee Address: CN Beijing
- Agency: Stites & Harbison PLLC
- Agent Cong Ding
- Priority: CN201110278403 20110919
- International Application: PCT/CN2011/080213 WO 20110927
- International Announcement: WO2013/040801 WO 20130328
- Main IPC: A61K9/06
- IPC: A61K9/06 ; A61K9/00 ; C07D401/12 ; C07D215/22 ; C07D215/233 ; A61K47/10 ; A61K9/20 ; A61K9/48
Abstract:
Provided in the present invention is a quinolyl-containing hydroxamic acid compound as shown in formula (I), at the same time also disclosed is the preparation method of the compound and the use thereof, and a pharmaceutical composition containing the quinolyl-containing hydroxamic acid compound. Such compounds are inhibitors of protein kinases and/or histone deacetylases, and can be used in the treatment of diseases caused by the abnormal activity of protein kinases and/or histone deacetylases, for example, tumors, etc.
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