Invention Grant
US09186416B2 Immunoconjugates, compositions for making them, and methods of making and use
有权
免疫缀合物，制备它们的组合物，以及制备和使用方法
- Patent Title: Immunoconjugates, compositions for making them, and methods of making and use
- Patent Title (中): 免疫缀合物，制备它们的组合物，以及制备和使用方法
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Application No.: US14471096Application Date: 2014-08-28
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Publication No.: US09186416B2Publication Date: 2015-11-17
- Inventor: Qian Zhang , Sanjeev Gangwar , Chin Pan , Daniel W. Derwin
- Applicant: Bristol-Myers Squibb Company
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Yuan Chao
- Main IPC: A61K47/48
- IPC: A61K47/48 ; C07K5/06 ; C07K5/10 ; C07K5/08 ; A61K31/404 ; C07D403/06 ; C07D403/14 ; C07D209/60
Abstract:
An immunoconjugate in which a phosphate-prodrugged DNA minor groove binding agent of formula (I), where X is a nucleophilically displaceable leaving group, is conjugated to an antibody or an antigen binding fragment of an antibody, and compounds that can be used for making such immunoconjugates, and uses of such immunoconjugates.
Public/Granted literature
- US20140364585A1 IMMUNOCONJUGATES, COMPOSITIONS FOR MAKING THEM, AND METHODS OF MAKING AND USE Public/Granted day:2014-12-11
Information query
