发明授权
- 专利标题： Aryloxyanilide imaging agents
- 专利标题（中）： 芳氧基苯胺显像剂
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申请号： US14295762申请日： 2014-06-04
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公开(公告)号： US09186424B2公开(公告)日： 2015-11-17
- 发明人: Harry John Wadsworth , Dennis O'Shea
- 申请人： GE Healthcare Limited
- 申请人地址： GB Buckinghamshire
- 专利权人： GE Healthcare Limited
- 当前专利权人： GE Healthcare Limited
- 当前专利权人地址： GB Buckinghamshire
- 代理机构： Parks Wood LLC
- 优先权： GB0921967.6 20091217
- 主分类号： A61K51/04
- IPC分类号： A61K51/04 ; A61K31/44 ; C07D307/79 ; C07D307/81 ; C07D317/46 ; C07D317/58 ; C07D319/18 ; C07D321/10 ; B01L3/00
摘要：
The present invention provides a novel radiolabelled aryloxyalinine derivative suitable for in vivo imaging. In comparison to known aryloxyalinine derivative in vivo imaging agents, the in vivo imaging agent of the present invention has better properties for in vivo imaging. The in vivo imaging agent of the present invention demonstrates good selective binding to the peripheral benzodiazepine receptor (PBR), in combination with good brain uptake and in vivo kinetics following administration to a subject.
公开/授权文献
- US20140288317A1 ARYLOXYANILIDE IMAGING AGENTS 公开/授权日：2014-09-25