Invention Grant
- Patent Title: Substituted 1,5-benzodiazepinones compounds
- Patent Title (中): 取代的1,5-苯并二氮杂化合物
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Application No.: US14429964Application Date: 2013-09-20
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Publication No.: US09187434B2Publication Date: 2015-11-17
- Inventor: Patrice Gill , Claude A. Quesnelle , Mark G. Saulnier , Ashvinikumar V. Gavai
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Gary D. Greenblatt
- International Application: PCT/US2013/060781 WO 20130920
- International Announcement: WO2014/047369 WO 20140327
- Main IPC: C07D401/04
- IPC: C07D401/04 ; C07D243/24 ; C07D243/14 ; A61K31/5513 ; A61K45/06
Abstract:
Disclosed are compounds of Formula (I): wherein: R1 is CH2CH2CF3; R2 is CH2CH2CF3, CH2(cyclopropyl), or phenyl; R3 is H or CH3; Ring A is phenyl or pyridinyl; and Rx, Ry, Ra, Rb, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.
Public/Granted literature
- US20150274679A1 SUBSTITUTED 1,5-BENZODIAZEPINONES COMPOUNDS Public/Granted day:2015-10-01
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