发明授权
US09187473B2 Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-b] pyridine and pyrazolo [3, 4-b] pyridine derivatives as protein kinase inhibitors
有权
取代5-(吡嗪-2-基)-1H-吡唑并[3,4-b]吡啶和吡唑并[3,4-b]吡啶衍生物作为蛋白激酶抑制剂
- 专利标题: Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-b] pyridine and pyrazolo [3, 4-b] pyridine derivatives as protein kinase inhibitors
- 专利标题(中): 取代5-(吡嗪-2-基)-1H-吡唑并[3,4-b]吡啶和吡唑并[3,4-b]吡啶衍生物作为蛋白激酶抑制剂
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申请号: US14290125申请日: 2014-05-29
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公开(公告)号: US09187473B2公开(公告)日: 2015-11-17
- 发明人: Hariprasad Vankayalapati , Rajendra P. Appalaneni , Y. Venkata Krishna Reddy
- 申请人: Arrien Pharmaceuticals LLC
- 申请人地址: US UT Salt Lake City
- 专利权人: ARRIEN PHARMACEUTICALS LLC
- 当前专利权人: ARRIEN PHARMACEUTICALS LLC
- 当前专利权人地址: US UT Salt Lake City
- 代理机构: Gibson & Dernier LLP
- 代理商 Timothy X. Gibson, Esq.
- 主分类号: C07D401/14
- IPC分类号: C07D401/14 ; A61K31/437 ; C07D471/04
摘要:
Substituted 5-(pyrazin-2-yl)-1H-pyrazolo[3,4-b]pyridine, 5-(pyrazin-2-yl)-1H-pyrrolo[2,3-b]pyridine and pyrazolo[3,4-b]pyridine derivatives according to formula I, II and VII, and methods for making same, which are inhibitors of constitutively activated Tyrosine Kinase-Like (TKL), CMGC protein kinases family members and can be useful in the treatment of Parkinson's disease, Alzheimer's disease, Down's Syndrome, Huntington's disease, other neurodegenerative and central nervous system disorders, cancer, metabolic disorders and inflammatory diseases. Also disclosed are pharmaceutical compositions including the compounds and methods of inhibiting wild type and/or mutated protein kinase activities of these families and the treatment of disorders associated therewith using compounds and pharmaceutical compositions including the compounds.