A logical communication path is provided between a target virtual machine (VM) and a host or application communicating with the VM. The target VM runs on a hypervisor host that has a hypervisor and a proxy agent. The hypervisor manages execution of the VM. A mapping is maintained indicating which VMs execute on which hosts. When the host or application is to send a message or packet to the target VM, the mapping is consulted and the hypervisor host hosting the target VM is identified. The message or packet, which may identify the target VM, is transmitted to the hypervisor host. A proxy agent at the hypervisor host selects a communication channel between the hypervisor and the target VM. The hypervisor then passes the message or packet through the selected channel to the target VM.