Invention Grant
- Patent Title: Human antibodies that bind human TNF-alpha and methods of preparing the same
- Patent Title (中): 结合人TNF-α的人抗体及其制备方法
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Application No.: US14522535Application Date: 2014-10-23
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Publication No.: US09193787B2Publication Date: 2015-11-24
- Inventor: Christopher M. Chumsae
- Applicant: ABBVIE INC.
- Applicant Address: US IL North Chicago
- Assignee: ABBVIE INC.
- Current Assignee: ABBVIE INC.
- Current Assignee Address: US IL North Chicago
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Main IPC: C07K1/18
- IPC: C07K1/18 ; C07K16/24
Abstract:
Methylglyoxal (MGO)-modified recombinant TNF-alpha antibodies (e.g., Adalimumab) are identified. MGO modification decreases binding between Adalimumab and TNF-alpha. Methods are disclosed for reducing the presence of MGO-modified antibodies in the production of Adalimumab TNF-alpha antibodies.
Public/Granted literature
- US20150045542A1 HUMAN ANTIBODIES THAT BIND HUMAN TNF-ALPHA AND METHODS OF PREPARING THE SAME Public/Granted day:2015-02-12
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