The present invention relates to a sensing structure of touch panel, which comprises a plurality of electrode groups disposed on a substrate. The substrate has a first side and a second side. Each electrode group comprises a first external electrode, a second external electrode, a plurality of internal electrodes, and a plurality of wires. The first external electrode is disposed on a first side; the second external electrode is disposed on the second side; the plurality of internal electrodes are disposed between the first external electrode and the second external electrode; and the plurality of wires are disposed on both sides of the electrode group alternately. Thereby, by disposing the first external electrode, the second external electrode, and the internal electrodes, all being zigzag, the disposable number of electrodes in each electrode group is increased. Accordingly, the sensitivity of touch sensing for the sensing structure of touch panel is enhanced.