Invention Grant
- Patent Title: Selective glycosidase inhibitors and uses thereof
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Application No.: US14129163Application Date: 2012-06-27
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Publication No.: US09199949B2Publication Date: 2015-12-01
- Inventor: Tong-Shuang Li , Ernest J. McEachern , David J. Vocadlo , Yuanxi Zhou , Harold G. Selnick
- Applicant: Tong-Shuang Li , Ernest J. McEachern , David J. Vocadlo , Yuanxi Zhou , Harold G. Selnick
- Applicant Address: CA Burnaby US NJ Rahway
- Assignee: Alectos Therapeutics Inc.,Merck Sharp & Dohme Corp.
- Current Assignee: Alectos Therapeutics Inc.,Merck Sharp & Dohme Corp.
- Current Assignee Address: CA Burnaby US NJ Rahway
- Agency: Clark & Elbing LLP
- International Application: PCT/CA2012/050434 WO 20120627
- International Announcement: WO2013/000085 WO 20130103
- Main IPC: C07D263/58
- IPC: C07D263/58 ; C07D413/04 ; C07D417/04 ; C07D277/60 ; A61K31/423 ; A61K31/428 ; C07D277/82 ; C12Q1/37 ; C07D263/52
Abstract:
The invention provides compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
Public/Granted literature
- US20150045346A1 SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF Public/Granted day:2015-02-12
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