The disclosure provides an electronic device with a Universal Serial Bus (USB) interface and a method for starting USB communication for a USB interface, so as to solve the problem that a mobile phone terminal device can be damaged easily when a charger shares one interface with USB communication in the conventional art. A control pin of the control circuit of the device is connected with a VCHG pin of a power management chip; an output pin of the control circuit is connected with a USB_VBUS pin of a USB interface chip; a power pin of the control circuit is connected with a fixed voltage input end which inputs a high level; and the control circuit is configured to output a fixed voltage from the output pin of the control circuit when detecting that the voltage of the control pin is more than a set threshold and output a low level from the output pin of the control circuit when detecting that the voltage of the control pin is less than the set threshold. The charging voltage (VCHG) of the handheld terminal product is only used as the control signal which is isolated from the voltage output to the USB_VBUS pin, so that the damage to the device is avoided.