A system (10) and method for manufacturing ophthalmic devices, in particular contact lenses or intraocular lenses, the system comprising: at least one injection molding machine for manufacturing a cup bottom part (202) and cup top part (204) to form a cast mold, a cooling station (30), an injection assembly (120) arranged for injecting an amount of monomeric material into the cup bottom part, a curing assembly (130), a first optical inspection assembly (140) for determining at least one first optical cup part parameter, a second optical inspection assembly (150) for determining at least one optical combination parameter of the combination of the cured monomeric material formed into a lens and the cup part that bears the lens, and an electronic control (14) provided with a calculation module for determining at least one optical lens parameter of the lens on the basis of the cup part parameter and the combination parameter. Possibly, production parameters can be adjusted on the basis of trend changes of the lens parameters of produced lenses.