Invention Grant
US09206402B2 Composition and formulation comprising recombinant human iduronate-2-sulfatase and preparation method thereof
有权
包含重组人类异戊二酸-2-硫酸酯酶的组合物和制剂及其制备方法
- Patent Title: Composition and formulation comprising recombinant human iduronate-2-sulfatase and preparation method thereof
- Patent Title (中): 包含重组人类异戊二酸-2-硫酸酯酶的组合物和制剂及其制备方法
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Application No.: US14128918Application Date: 2012-06-15
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Publication No.: US09206402B2Publication Date: 2015-12-08
- Inventor: Thong-Gyu Jin , Yo Kyung Chung , Sang Hoon Paik , Yoo Chang Park , Jinwook Seo , Yong Woon Choi , Jong Mun Son , Yong-Chul Kim
- Applicant: Thong-Gyu Jin , Yo Kyung Chung , Sang Hoon Paik , Yoo Chang Park , Jinwook Seo , Yong Woon Choi , Jong Mun Son , Yong-Chul Kim
- Applicant Address: KR Yongin-si KR Yongin-si
- Assignee: GREEN CROSS CORPORATION,MediGeneBio Corporation
- Current Assignee: GREEN CROSS CORPORATION,MediGeneBio Corporation
- Current Assignee Address: KR Yongin-si KR Yongin-si
- Agency: Sughrue Mion, PLLC
- Priority: KR10-2012-0012718 20120208
- International Application: PCT/KR2012/004734 WO 20120615
- International Announcement: WO2012/177020 WO 20121227
- Main IPC: C12N9/16
- IPC: C12N9/16 ; A61K38/46
Abstract:
Disclosed is a composition comprising recombinant iduronate-2-sulfatase (IDS). The glycosylation pattern and formylglycine content of the IDS composition are different from those of Elaprase and have superior pharmaceutical efficacy and are safer than the conventional agent and thus can be effectively used for the therapy of Hunter syndrome.
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