发明授权
US09216971B2 Quaternary ammonium compounds useful as muscarinic receptor antagonists
有权
可用作毒蕈碱受体拮抗剂的季铵化合物
- 专利标题： Quaternary ammonium compounds useful as muscarinic receptor antagonists
- 专利标题（中）： 可用作毒蕈碱受体拮抗剂的季铵化合物
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申请号： US14335097申请日： 2014-07-18
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公开(公告)号： US09216971B2公开(公告)日： 2015-12-22
- 发明人: Craig Husfeld , YuHua Ji , Rick Lee , Li Li , YongQi Mu , Cameron Smith , Johnny Uy
- 申请人： Craig Husfeld , YuHua Ji , Rick Lee , Li Li , YongQi Mu , Cameron Smith , Johnny Uy
- 申请人地址： US CA South San Francisco
- 专利权人： Theravance Biopharma R&D IP, LLC
- 当前专利权人： Theravance Biopharma R&D IP, LLC
- 当前专利权人地址： US CA South San Francisco
- 代理商 Jeffrey A. Hagenah
- 主分类号： C07D405/12
- IPC分类号： C07D405/12 ; C07D409/12 ; C07D401/12 ; C07D409/14 ; C07D205/04 ; C07D211/26 ; C07D211/58 ; C07D405/06 ; C07D409/06
摘要：
The invention provides compounds of the formula: in salt or zwitterionic form or a pharmaceutically acceptable salt thereof, wherein R1-6, a, Z and Q are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.
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