Provided are a method and apparatus for transmitting a signal of a multi-node system employing a plurality of nodes distributed geographically and a base station that can be controlled by being connected with each of the plurality of nodes. The method includes: mapping a plurality of codewords to a plurality of streams; mapping the plurality of streams to at least one node among the plurality of nodes; performing multiple input multiple output (MIMO) precoding to map the streams mapped to the at least one node to at least one transmit antennas; and transmitting a signal subjected to the MIMO precoding to a user equipment.