Various methods for wireless communication in a device with co-existed/co-located radios are provided. Multiple communication radio transceivers are co-existed/co-located in a user equipment (UE) having in-device coexistence (IDC) capability, which may result in IDC interference. For example, the UE is equipped with both LTE radio and some ISM band applications such as WiFi and Bluetooth modules. In a first method, the network identifies IDC capability by UE identification (e.g., UE ID). In a second method, the UE intentionally performs cell selection or reselection to cells in non-ISM frequency bands. In a third method, the UE signals the existence of ISM band applications via capability negotiation. In a fourth method, the UE signals the activation of ISM band applications by signaling messages (e.g., RRC message or MAC CE). Under the various methods, the UE and its serving eNB can apply FDM or TDM solutions to mitigate the IDC interference.