A power control method to mitigate in-device coexistence (IDC) interference is provided. A wireless communication device (UE) is equipped with a first LTE radio module and a second co-located WiFi/BT/GSNN radio module. Upon detecting coexistence or IDC interference, the UE applies power control method to mitigate the interference. In a first embodiment, the LTE radio module adjusts its power parameters locally without informing the serving eNB. In a second embodiment, the LTE radio module adjusts its power parameters and implicit informs the eNB through existing PHR reporting. In a third embodiment, the LTE radio module changes its power or power class and explicitly informs the eNB through UE capability or new RRC message or MAC CE. Power control can be used as a low cost and lightweight solution before applying other heavyweight solutions that either require more resource or control overhead, or have higher impact on throughput.