Invention Grant
- Patent Title: Substituted phthalazinones as rock inhibitors
- Patent Title (中): 取代的2,3-二氮杂萘酮作为岩石抑制剂
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Application No.: US14157564Application Date: 2014-01-17
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Publication No.: US09221767B2Publication Date: 2015-12-29
- Inventor: Peter W. Glunz , Yan Zou , Mimi L. Quan
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Hong Liu
- Main IPC: A61K31/502
- IPC: A61K31/502 ; C07D237/32 ; C07D401/10 ; C07D401/12 ; C07D403/10 ; C07D403/12 ; C07D405/12 ; C07D413/12 ; C07D417/12 ; C07D417/14 ; C07D513/04 ; C07D217/24 ; C07D413/10 ; C07D417/10 ; C07D471/04 ; C07D487/04 ; C07D491/048
Abstract:
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
Public/Granted literature
- US20140206686A1 PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS Public/Granted day:2014-07-24
Information query
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