Invention Grant
- Patent Title: Fibronectin based scaffold domain proteins that bind PCSK9
- Patent Title (中): 结合PCSK9的基于纤连蛋白的支架结构域蛋白
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Application No.: US13835639Application Date: 2013-03-15
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Publication No.: US09234027B2Publication Date: 2016-01-12
- Inventor: Ray Camphausen , Jonathan H. Davis , Sharon T. Cload , Fabienne M. Denhez , Amna Saeed-Kothe , Dasa Lipovsek , Ching-Hsiung Frederick Lo , Chee Meng Low , Bowman Miao , Tracy S. Mitchell , Rex A. Parker , Ginger C. Rakestraw , Katie A. Russo , Doree F. Sitkoff
- Applicant: Bristol-Myers Squibb Company
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agency: Morgan, Lewis & Bockius LLP
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/38 ; C07K14/78 ; A61K38/39 ; C12N9/64
Abstract:
The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein.
Public/Granted literature
- US20130210703A1 FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND PCSK9 Public/Granted day:2013-08-15
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