Systems and methods of the present disclosure provide for caching, by a device intermediary to a client and a database, a result of a structured query language (SQL) query request. In some embodiments, the device intermediary to a plurality of clients and a database receives a SQL response from the database to a first SQL query request of a client of the plurality of clients. The device may maintain a cache of SQL responses from the database. The device may identify that the first SQL query request matches a rule of a policy for caching SQL responses from the database. The policy may include a cache action to take when the rule is matched. The device may perform, responsive to the policy, on the SQL response the cache action identified by the policy.