Technologies are directed to prevention of malicious attacks through cartography of co-processors at a datacenter. According to some examples, configuration data to create a co-processor at a field programmable gate array (FPGA) may be received at a configuration controller. The configuration controller may determine unused arrangements for the co-processor and unused placements at the FPGA corresponding to the unused arrangements. The used arrangements and the unused placements, associated with a type of the co-processor, may be stored in a configuration matrix. One of the unused arrangements and one of the unused placements corresponding to the selected unused arrangement may then be selected by the configuration controller to create the co-processor.