发明授权
- 专利标题： Molecular probe for imaging of pancreatic islets and use of the same
- 专利标题（中）： 胰岛成像用分子探针及其用途
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申请号： US12893896申请日： 2010-09-29
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公开(公告)号： US09238083B2公开(公告)日： 2016-01-19
- 发明人: Hideo Saji , Nobuya Inagaki , Kentaro Toyoda , Hiroyuki Kimura , Konomu Hirao , Kenji Nagakawa , Hirokazu Matsuda
- 申请人： Hideo Saji , Nobuya Inagaki , Kentaro Toyoda , Hiroyuki Kimura , Konomu Hirao , Kenji Nagakawa , Hirokazu Matsuda
- 申请人地址： JP Kyoto JP Kyoto
- 专利权人： Kyoto University,ARKRAY, Inc.
- 当前专利权人： Kyoto University,ARKRAY, Inc.
- 当前专利权人地址： JP Kyoto JP Kyoto
- 代理机构： Morgan, Lewis & Bockius LLP
- 优先权： JP2009-228658 20090930
- 主分类号： A61K51/08
- IPC分类号： A61K51/08 ; C07K14/00
摘要：
A molecular probe for imaging of pancreatic islets is provided. The molecular probe includes a polypeptide represented by the following formula (1), or a polypeptide that has a homology with the foregoing polypeptide. (SEQ ID NO. 1) Z-HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPSX-NH2 (1) Wherein “X” represents a lysine residue, an amino group of a side chain of the lysine residue being labeled with a group represented by the following chemical formula (I), wherein A represents an aromatic hydrocarbon group or an aromatic heterocyclic group; R1 represents a substituent that contains 11C, 13N, 15O, 18F, 64Cu, 67Ga, 68Ga, 75Br, 76Br, 77Br, 99mTc, 111In, 123I, 124I, 125I, or 131I; R2 represents either a hydrogen atom, or a substituent different from that represented by R1; and R3 represents any one of a bond, an alkylene group having 1 to 6 carbon atoms, and an oxyalkylene group having 1 to 6 carbon atoms.
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