Multi-conductor cables for telecommunication systems include a plurality of fiber-optic conductors and/or power conductors extending within an outer jacket in a main body portion of the cable, and extending outside of the outer jacket in a break-out portion of the cable. A break-out boot may be attached to the outer jacket and may surround the conductors in a break-out portion of the cable. Potting material may be provided in the break-out boot within spaces between adjacent conductors to provide innovative sealing of the break-out portion.