The present invention provides a method of interactive gaming applied to an interactive case and a tablet, wherein the interactive case is arranged to be attached on the tablet, and the interactive case includes a transmission port arranged to communicate with the tablet and a plurality of notches. The method of interactive game includes determining whether at least one accessory medal is connected to the notch; when one of the accessory medals is connected to one of the notches, retrieving a predetermined data stored in the connected accessory medal; identifying the connected accessory medal according to the predetermined data of the connected accessory medal; and performing an application corresponding to the connected accessory medal.