Invention Grant
US09242940B2 N-substituted bis(fluoroalkyl)-1,4-benzodiazepinone compounds
有权
N-取代的双（氟烷基）-1,4-苯并二氮杂酮化合物
- Patent Title: N-substituted bis(fluoroalkyl)-1,4-benzodiazepinone compounds
- Patent Title (中): N-取代的双（氟烷基）-1,4-苯并二氮杂酮化合物
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Application No.: US14429945Application Date: 2013-09-20
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Publication No.: US09242940B2Publication Date: 2016-01-26
- Inventor: Wen-Ching Han , Patrice Gill , Ashvinikumar V. Gavai , Claude A. Quesnelle
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Gary D. Greenblatt
- International Application: PCT/US2013/060836 WO 20130920
- International Announcement: WO2014/047393 WO 20140327
- Main IPC: C07D401/04
- IPC: C07D401/04 ; C07D243/18 ; C07D491/04 ; C07D243/16 ; C07D243/26 ; A61K31/138 ; A61K31/337 ; A61K31/506 ; A61K31/5513 ; A61K31/555 ; A61K31/573 ; A61K45/06 ; C07D491/056
Abstract:
Disclosed are compounds of Formula (I): wherein: R1 is —CH2CH2CF3; R2 is —CH2CH2CF3, or —CH2CH2CH2CF3; R3 is —CH2CF3, —CH2CN, —CH2(cyclopropyl), pyridinyl, chloropyridinyl, or tetrahydropyranyl; Ring A is phenyl or pyridinyl; Ra, Rb, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.
Public/Granted literature
- US20150246892A1 N-SUBSTITUTED BIS(FLUOROALKYL)-1,4-BENZODIAZEPINONE COMPOUNDS Public/Granted day:2015-09-03
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