Invention Grant
- Patent Title: Alkyl, fluoroalkyl-1,4-benzodiazepinone compounds
- Patent Title (中): 烷基，氟烷基-1,4-苯并二氮杂酮化合物
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Application No.: US14429935Application Date: 2013-09-20
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Publication No.: US09242941B2Publication Date: 2016-01-26
- Inventor: Ashvinikumar V. Gavai , Yufen Zhao , Daniel O'Malley , Claude A. Quesnelle , Brian E. Fink , Derek J. Norris , Wen-Ching Han , George V. DeLucca
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Gary D. Greenblatt
- International Application: PCT/US2013/060799 WO 20130920
- International Announcement: WO2014/047374 WO 20140327
- Main IPC: C07D401/04
- IPC: C07D401/04 ; C07D243/24 ; C07F9/12 ; C07F9/645 ; A61K31/5513 ; A61K31/675 ; A61K45/06 ; C07D403/12
Abstract:
Disclosed are compounds of Formula (I) and/or salts thereof: (I) wherein: R1 is CH2CH2CF3; R2 is CH2(cyclopropyl), CH(CH3)(cyclopropyl), or CH2CH2CH3; R3 is H, CH3, or Rx; R4 is H or Ry; and Rx, Ry, Ra, Rb, Rc, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer. The compounds of Formula (I) also include prodrugs of the Notch inhibitor compounds.
Public/Granted literature
- US20150239851A1 ALKYL, FLUOROALKYL-1,4-BENZODIAZEPINONE COMPOUNDS Public/Granted day:2015-08-27
Information query
