Invention Grant
- Patent Title: Pyrazolyl derivatives as Syk inhibitors
- Patent Title (中): 吡唑基衍生物作为Syk抑制剂
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Application No.: US14409133Application Date: 2013-06-18
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Publication No.: US09242984B2Publication Date: 2016-01-26
- Inventor: Michelle R. Machacek , Michael D. Altman , Eric T. Romeo , Dilrukshi Vitharana , Brandon Cash , Tony Siu , Hua Zhou , Matthew Christopher , Solomon D. Kattar , Andrew M. Haidle , Kaleen Konrad Childers , Matthew L. Maddess , Michael H. Reutershan , Yves Ducharme , David J. Guerin , Kerrie Spencer , Christian Beaulieu , Vouy Linh Truong , Daniel Guay , Alan B. Northrup , Brandon M. Taoka , Jongwon Lim , Christian Fischer , John W. Butcher , Ryan D. Otte , Binyuan Sun , John Michael Ellis
- Applicant: Merck Sharp & Dohme Corp. , Merck Canada Inc.
- Applicant Address: US NJ Rahway CA Quebec
- Assignee: Merck Sharp & Dohme Corp.,Merck Canada Inc.
- Current Assignee: Merck Sharp & Dohme Corp.,Merck Canada Inc.
- Current Assignee Address: US NJ Rahway CA Quebec
- Agent Eric A. Meade; Catherine D. Fitch
- International Application: PCT/US2013/046219 WO 20130618
- International Announcement: WO2013/192125 WO 20131227
- Main IPC: C07D401/00
- IPC: C07D401/00 ; A61K31/00 ; C07D471/04 ; C07D403/12 ; C07D401/14 ; C07D405/14 ; C07D413/14 ; C07D403/14 ; C07D409/14
Abstract:
The present invention provides novel pyrazole derivatives of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
Public/Granted literature
- US20150191461A1 PYRAZOLYL DERIVATIVES AS SYK INHIBITORS Public/Granted day:2015-07-09
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