Invention Grant
- Patent Title: Compositions and method for treatment of ischemic neuronal reperfusion injury
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Application No.: US14626126Application Date: 2015-02-19
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Publication No.: US09248118B2Publication Date: 2016-02-02
- Inventor: Harpal S. Mangat , Pradeep K. Karla
- Applicant: Howard University
- Applicant Address: US DC Washington
- Assignee: Howard University
- Current Assignee: Howard University
- Current Assignee Address: US DC Washington
- Agency: Fitch Even Tabin & Flannery LLP
- Main IPC: A61K31/4178
- IPC: A61K31/4178 ; C07D405/12 ; A61K45/06 ; A61K38/05

Abstract:
A method and composition for the treatment of ischemic neuronal reperfusion injury are provided. The composition can include a compound which is a combination of dantrolene and a residue of FMOC-valine. This composition can be used to provide a faster and higher CNS penetration than heretofore experienced with dantrolene. In another form, dantrolene may be formulated as a pro-drug, a pro-pro-drug and the like.
Public/Granted literature
- US20150374667A1 Compositions And Method For Treatment Of Ischemic Neuronal Reperfusion Injury Public/Granted day:2015-12-31
Information query
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