Invention Grant
US09249162B2 Substituted [1,2,4]triazolo[1,5-a]pyridines as PDE-10 inhibitors
有权
取代的[1,2,4]三唑并[1,5-a]吡啶作为PDE-10抑制剂
- Patent Title: Substituted [1,2,4]triazolo[1,5-a]pyridines as PDE-10 inhibitors
- Patent Title (中): 取代的[1,2,4]三唑并[1,5-a]吡啶作为PDE-10抑制剂
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Application No.: US14298691Application Date: 2014-06-06
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Publication No.: US09249162B2Publication Date: 2016-02-02
- Inventor: John Emmerson Campbell , Philip Jones , Michael Charles Hewitt
- Applicant: Sunovion Pharmaceuticals Inc.
- Applicant Address: US MA Marlborough
- Assignee: Sunovion Pharmaceuticals Inc.
- Current Assignee: Sunovion Pharmaceuticals Inc.
- Current Assignee Address: US MA Marlborough
- Agency: Choate Hall & Stewart LLP
- Main IPC: A61K31/4353
- IPC: A61K31/4353 ; C07D471/04 ; C07D519/00 ; A61K45/06 ; C07D487/04 ; A61K31/4375 ; A61K31/4745 ; A61K31/4985 ; A61K31/519 ; A61K31/5383
![Substituted [1,2,4]triazolo[1,5-a]pyridines as PDE-10 inhibitors](/abs-image/US/2016/02/02/US09249162B2/abs.jpg.150x150.jpg)
Abstract:
Provided herein are compounds of formula A-L-B, and pharmaceutically acceptable salts and stereoisomers thereof, wherein A is wherein L, B and R3 are defined herein, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds and compositions provided herein are PDE-10 inhibitors and useful, e.g., for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.
Public/Granted literature
- US20140288062A1 HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF Public/Granted day:2014-09-25
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