发明授权
US09249179B2 Galactose cluster-pharmacokinetic modulator targeting moiety for siRNA
有权
用于siRNA的半乳糖簇 - 药代动力学调节剂靶向部分
- 专利标题： Galactose cluster-pharmacokinetic modulator targeting moiety for siRNA
- 专利标题（中）： 用于siRNA的半乳糖簇 - 药代动力学调节剂靶向部分
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申请号： US13327271申请日： 2011-12-15
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公开(公告)号： US09249179B2公开(公告)日： 2016-02-02
- 发明人: Philipp Hadwiger , Torsten Hoffmann , Eric A. Kitas , Peter Mohr , Ingo Roehl , Linda Valis , David B. Rozema , David L. Lewis , Darren H. Wakefield
- 申请人： Philipp Hadwiger , Torsten Hoffmann , Eric A. Kitas , Peter Mohr , Ingo Roehl , Linda Valis , David B. Rozema , David L. Lewis , Darren H. Wakefield
- 申请人地址： US WI Madison
- 专利权人： Arrowhead Madison Inc.
- 当前专利权人： Arrowhead Madison Inc.
- 当前专利权人地址： US WI Madison
- 代理商 Kirk Ekena
- 主分类号： A61K31/7088
- IPC分类号： A61K31/7088 ; C07H21/02
摘要：
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cell in vivo. The pharmacokinetic modulator improve in vivo targeting compared to the targeting ligand alone. Targeting ligand-pharmacokinetic modulator targeting moiety targeted RNAi polynucleotides can be administered in vivo alone or together with co-targeted delivery polymers.
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