Invention Grant
- Patent Title: Human growth hormone receptor antagonist antibodies and methods of use thereof
- Patent Title (中): 人生长激素受体拮抗剂抗体及其使用方法
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Application No.: US14367483Application Date: 2012-12-10
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Publication No.: US09249224B2Publication Date: 2016-02-02
- Inventor: Sara Iva Siebel , Edward Derrick Pascua , Chia-Yang Lin , Javier Fernando Chaparro Riggers
- Applicant: RINAT NEUROSCIENCE CORP.
- Applicant Address: US CA South San Francisco
- Assignee: RINAT NEUROSCIENCE CORP.
- Current Assignee: RINAT NEUROSCIENCE CORP.
- Current Assignee Address: US CA South San Francisco
- Agent Susan L. Wang
- International Application: PCT/IB2012/057151 WO 20121210
- International Announcement: WO2013/093707 WO 20130627
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K39/395 ; A61K39/00
Abstract:
The present invention provides antagonizing antibodies that bind to growth hormone receptor (GHR). The invention further relates to therapeutic methods for use of these antibodies to reduce IGF-1 levels and/or for the treatment and/or prevention of diseases associated with excessive IGF-1, including treatment of acromegaly, gigantism, cancer, diabetic nephropathy, arthritis, and lung inflammation.
Public/Granted literature
- US20140356359A1 HUMAN GROWTH HORMONE RECEPTOR ANTAGONIST ANTIBODIES AND METHODS OF USE THEREOF Public/Granted day:2014-12-04
Information query
