A system and method are disclosed for controlling an engine using pre-chamber ignition. According to at least one aspect of the present disclosure, the system includes a pre-chamber ignition system in communication with a combustion cylinder of the engine. The ignition system includes a pre-chamber having a pre-chamber injector, an igniter, and a pre-chamber port structured to introduce a purge gas into the pre-chamber. The system further includes an exhaust gas recirculation system to dilute a main charge introduced into the cylinder. The ignition system improves engine efficiency and lowers emissions.